Katawa Shoujo is a bishoujo-style visual novel set in the fictional Yamaku High School for disabled children, located somewhere in modern Japan. Hisao Nakai, who has had a congenital heart disorder diagnosed just a few months ago, finds his life turned upside down when he moves to a new town and school after a long hospitalization. Despite his difficulties, Hisao is able to find friends and eventually have romantic relationships with one of five main female characters.